Critical Micelle Concentrations (CMCs) - Avanti^® Polar Lipids

Definition

The critical micelle concentration (CMC) can be approximately defined as the lipid monomer concentration at which appreciable amounts (>5% of total) of micellar aggregates first begin to appear in the equilibrium: nM1<=>Mn

CMC Values

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† Data provided by Dr. Rinku Majumder, Department of Biochemistry, The University of North Carolina – Chapel Hill.

Lipid	CMC (mM)
5:0 PC	90
6:0 PC	15
7:0 PC	1.4
8:0 PC	0.27
9:0 PC	0.029
10:0 PC	0.005
12:0 PC	90 nM
14:0 PC	6 nM
16:0 PC	0.46 nM
8:0 PG	1.21
10:0 PG	0.42
12:0 PG	0.13
14:0 PG	0.011
4:0 PS (5mM Ca2+)†	4
5:0 PS (5mM Ca2+)†	2
6:0 PS (5mM Ca2+)†	1.2
7:0 PS (5mM Ca2+)†	0.8
8:0 PS (5mM Ca2+)†	0.4
8:0 PS	2.282
10:0 PS	0.096
8:0 Lyso PC	60
10:0 Lyso PC	6-8
12:0 Lyso PC	0.4-0.9
14:0 Lyso PC	0.043-0.090
16:0 Lyso PC	4-8.3 µM
18:0 Lyso PC	0.4 µM

Lipid Acronyms Key

PC = phosphatidylcholine
PG = phosphatidylglycerol
PS = phosphatidylserine

CMC’s were determined in house by using a Pyrene Fluorescence technique or were obtained from the literature. Many of the literature values were confirmed by our in-house method.

The method is generally outlined by: Fluorescent Probes For Critical Micelle Concentration

References

1. Derek M. 2013. Handbook of Lipid Bilayers. ISBN 0849332559. CRC Press, Inc..