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Merck
  • Evolutionary screening of biomimetic coatings for selective detection of explosives.

Evolutionary screening of biomimetic coatings for selective detection of explosives.

Langmuir : the ACS journal of surfaces and colloids (2008-03-28)
Justyn W Jaworski, Digvijay Raorane, Jin H Huh, Arunava Majumdar, Seung-Wuk Lee
要旨

Susceptibility of chemical sensors to false positive signals remains a common drawback due to insufficient sensor coating selectivity. By mimicking biology, we have demonstrated the use of sequence-specific biopolymers to generate highly selective receptors for trinitrotoluene and 2,4-dinitrotoluene. Using mutational analysis, we show that the identified binding peptides recognize the target substrate through multivalent binding with key side chain amino acid elements. Additionally, our peptide-based receptors embedded in a hydrogel show selective binding to target molecules in the gas phase. These experiments demonstrate the technique of receptor screening in liquid to be translated to selective gas-phase target binding, potentially impacting the design of a new class of sensor coatings.

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Sigma-Aldrich
Atto425-ストレプトアビジン, BioReagent, suitable for fluorescence