- Palladium-catalyzed stereoselective formation of alpha-O-glycosides.
Palladium-catalyzed stereoselective formation of alpha-O-glycosides.
Organic letters (2007-07-10)
Brandon P Schuff, Gregory J Mercer, Hien M Nguyen
PMID17616145
要旨
A novel method for palladium-catalyzed stereoselective formation of alpha-O-glycosides has been developed. This strategy relies on the palladium-biaryl phosphine catalyst-glycal donor complexation to control the anomeric selectivity. It does not depend on the nature of the protecting groups on the substrates, thus eliminating the need for cumbersome protecting group manipulations.
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