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Merck
  • Towards the total chemical synthesis of integral membrane proteins: a general method for the synthesis of hydrophobic peptide-thioester building blocks.

Towards the total chemical synthesis of integral membrane proteins: a general method for the synthesis of hydrophobic peptide-thioester building blocks.

Tetrahedron letters (2007-03-05)
Erik C B Johnson, Stephen B H Kent
要旨

Modification of a peptide-(α)thioester with a sequence of six arginines on the thioester leaving group can render soluble all peptides derived from a polytopic integral membrane protein. This strategy greatly simplifies the synthesis of peptide-(α)thioester building blocks for the total chemical synthesis of integral membrane proteins by native chemical ligation.

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製品内容

Sigma-Aldrich
2‐アミノ‐2‐メチル‐1‐プロパノール, ~5% Water, technical grade, 95%
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在庫状況
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