- Synthesis of a chiral aziridine derivative as a versatile intermediate for HIV protease inhibitors.
Synthesis of a chiral aziridine derivative as a versatile intermediate for HIV protease inhibitors.
Organic letters (2001-07-21)
B M Kim, S J Bae, S M So, H T Yoo, S K Chang, J H Lee, J Kang
PMID11463313
要旨
[reaction: see text] Chiral aziridine derivative 1 was prepared from D-tartaric acid. This compound could be utilized as a common intermediate for the synthesis of hydroxyethylamine class HIV protease inhibitors such as saquinavir, amprenavir, or nelfinavir.
材料