- Enantioselective iridium-catalyzed carbonyl allylation from the alcohol oxidation level via transfer hydrogenation: minimizing pre-activation for synthetic efficiency.
Enantioselective iridium-catalyzed carbonyl allylation from the alcohol oxidation level via transfer hydrogenation: minimizing pre-activation for synthetic efficiency.
Chemical communications (Cambridge, England) (2009-12-22)
Soo Bong Han, In Su Kim, Michael J Krische
PMID20024203
要旨
Existing methods for enantioselective carbonyl allylation, crotylation and tert-prenylation require stoichiometric generation of pre-metallated nucleophiles, and often employ stoichiometric chiral modifiers. Under the conditions of transfer hydrogenation employing an ortho-cyclometallated iridium C,O-benzoate catalyst, enantioselective carbonyl allylations, crotylations and tert-prenylations are achieved in the absence of stoichiometric metallic reagents or stoichiometric chiral modifiers. Moreover, under transfer hydrogenation conditions, primary alcohols function dually as hydrogen donors and aldehyde precursors, enabling enantioselective carbonyl addition directly from the alcohol oxidation level.
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イリジウム, wire reel, 0.5m, diameter 0.5mm, as drawn, 99.9%
イリジウム, wire reel, 0.5m, diameter 0.38mm, as drawn, 99.9%
イリジウム, rod, 25mm, diameter 3.0mm, as drawn, 99.9%
イリジウム, rod, 25mm, diameter 2.0mm, as drawn, 99.9%
イリジウム, rod, 50mm, diameter 2.0mm, as drawn, 99.9%
イリジウム, wire, straight, 100mm, diameter 0.5mm, as drawn, 99.9%
イリジウム, foil, 25x25mm, thickness 0.125mm, as rolled, 99.9%
イリジウム, wire reel, 0.05m, diameter 0.8mm, as drawn, 99.9%
イリジウム, microfoil, disks, 10mm, thinness 0.1μm, specific density 224μg/cm2, permanent mylar 3.5μm support, 99.9%
イリジウム, rod, 50mm, diameter 3.0mm, as drawn, 99.9%
イリジウム, foil, 25x25mm, thickness 0.15mm, as rolled, 99.9%
イリジウム, foil, 0.025m coil, thickness 0.05mm, coil width .5mm, as rolled, 99.9%
イリジウム, microfoil, disks, 25mm, thinness 0.1μm, specific density 224μg/cm2, permanent mylar 3.5μm support, 99.9%
イリジウム, wire reel, 0.05m, diameter 0.1mm, as drawn, 99.9%
イリジウム, wire reel, 0.1m, diameter 0.15mm, as drawn, 99.9%
イリジウム, wire reel, 1m, diameter 0.125mm, as drawn, 99.9%
イリジウム, foil, 25x25mm, thickness 0.25mm, as rolled, 99.9%
イリジウム, foil, light tested, 25x25mm, thickness 0.025mm, as rolled, 99.9%
イリジウム, foil, light tested, 25x25mm, thickness 0.05mm, as rolled, 99.9%
イリジウム, wire reel, 0.2m, diameter 0.125mm, as drawn, 99.9%
イリジウム, wire reel, 0.3m, diameter 0.5mm, as drawn, 99.9%
イリジウム, wire, straight, 200mm, diameter 0.5mm, as drawn, 99.9%
イリジウム, wire, straight, 50mm, diameter 1.0mm, as drawn, 99.9%
イリジウム, foil, 0.1m coil, thickness 0.05mm, coil width .5mm, as rolled, 99.9%
イリジウム, wire reel, 0.1m, diameter 0.075mm, as drawn, 99.9%
イリジウム, wire reel, 0.2m, diameter 0.125mm, as drawn, 99.5%
イリジウム, wire reel, 0.2m, diameter 0.5mm, as drawn, 99.9%