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  • Recent progress in the development of coumarin derivatives as potent anti-HIV agents.

Recent progress in the development of coumarin derivatives as potent anti-HIV agents.

Medicinal research reviews (2003-03-21)
Donglei Yu, Madoka Suzuki, Lan Xie, Susan L Morris-Natschke, Kuo-Hsiung Lee
要旨

Numerous plant-derived compounds have been evaluated for inhibitory effects against HIV replication, and some coumarins have been found to inhibit different stages in the HIV replication cycle. This review article describes recent progress in the discovery, structure modification, and structure-activity relationship studies of potent anti-HIV coumarin derivatives. A dicamphanoyl-khellactone (DCK) analog, which was discovered and developed in our laboratory, and calanolide A are currently in preclinical studies and clinical trials, respectively.

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製品内容

Sigma-Aldrich
クマリン, ≥99% (HPLC)
Supelco
クマリン, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland
クマリン, primary reference standard
クマリン, European Pharmacopoeia (EP) Reference Standard