- One-pot preparation of Oxazol-5(4H)-ones from amino acids in aqueous solvents.
One-pot preparation of Oxazol-5(4H)-ones from amino acids in aqueous solvents.
Chemical & pharmaceutical bulletin (2012-07-14)
Hikaru Fujita, Munetaka Kunishima
PMID22790826
要旨
A method for one-pot synthesis of oxazol-5(4H)-ones has been developed using 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (DMT-MM), which is available for the activation of carboxylic acids in an aqueous solvent. The oxazolones were prepared by the N-acylation of amino acids with carboxylic acids and the subsequent cyclodehydration of the resulting N-acylamino acids by the addition of N,N-diethylaniline. Since both these reactions proceed effectively with the same coupling reagent, DMT-MM, in aqueous solvents, the procedure is simplified and becomes easy to perform. In addition, 5-(triazinyloxy)oxazole derivatives have been synthesized by controlling the basicity of the reaction system.
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