- First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase.
First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase.
Chemical communications (Cambridge, England) (2011-04-01)
Guillaume Mercey, Tristan Verdelet, Géraldine Saint-André, Emilie Gillon, Alain Wagner, Rachid Baati, Ludovic Jean, Florian Nachon, Pierre-Yves Renard
PMID21451868
要旨
Nerve agents are highly toxic organophosphorus compounds with strong inhibition potency against acetylcholinesterase (AChE). Herein, we describe two first extremely promising uncharged reactivators for poisoned human AChE with a superior or similar in vitro ability to reactivate the enzyme as compared to that of HI-6, obidoxime, TMB-4 and HLö-7.
材料