- Preparation of useful synthetic intermediates of Taxol analogs, cyclooctenone derivatives.
Preparation of useful synthetic intermediates of Taxol analogs, cyclooctenone derivatives.
Chemical & pharmaceutical bulletin (1998-01-20)
K Yamada, T Tozawa, K Saitoh, T Mukaiyama
PMID9433783
要旨
Stereoselective syntheses of omega-(alpha-bromoketo) octanals and nonanal with oxygenated functions and formation of the corresponding eight-membered carbocyclic aldols by subsequent samarium(II)-mediated cyclization are demonstrated. Cyclooctenones deoxygenated at the C2 or C10 position in the taxane framework are prepared by dehydration of the above aldols.
材料