コンテンツへスキップ
Merck
  • Cycloaromatization approach to polysubstituted indolizines from 2-acetylpyrroles: decoration of the pyridine unit.

Cycloaromatization approach to polysubstituted indolizines from 2-acetylpyrroles: decoration of the pyridine unit.

The Journal of organic chemistry (2013-01-08)
Jin Ho Lee, Ikyon Kim
要旨

A new synthetic route to indolizines with various substituents on the pyridine moiety was developed by utilizing a facile cycloaromatization of 2-acetylpyrrole derivatives. Without isolation, the resulting intermediates were allowed to react with various electrophiles to afford a range of indolizines. In particular, Suzuki-Miyaura cross-coupling of O-triflates with (hetero)arylboronic acids permitted introduction of diverse substituents at the C8 position of an indolizine skeleton.

材料
製品番号
ブランド
製品内容

Sigma-Aldrich
2-アセチルピロール, ReagentPlus®, 99%
Sigma-Aldrich
メチル 2-ピロリルケトン, ≥98%, FG