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Merck
  • N-phenylmaleimide derivatives as mimetic agents of the pro-inflammatory process: myeloperoxidase activation.

N-phenylmaleimide derivatives as mimetic agents of the pro-inflammatory process: myeloperoxidase activation.

Pharmacological reports : PR (2011-08-23)
Vânia F Noldin, Silvana V G Vigil, Rafael De Liz, Valdir Cechinel-Filho, Tânia S Fröde, Tânia B Creczynski-Pasa
要旨

Myeloperoxidase (MPO) is an important enzyme that catalyzes the reaction between hydrogen peroxide and chloride to generate hypochlorous acid, which oxidizes a range of biomolecules and has been associated with inflammatory diseases. The synthetic compounds N-phenylmaleimide (NFM) and 4-methyl-N-phenylmaleimide (Me-NFM) increased the MPO activity in vitro (of isolated enzyme and in isolated cells after animal treatment) and in vivo assays. MPO-induction may represent a good model system to investigate the molecular and cellular mechanisms of oxidative cell injury induced by activated neutrophils, and the interactions between damaging species involved in the respiratory burst.

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製品内容

Sigma-Aldrich
N-フェニルマレイミド, 97%