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Influence of architecture on the kinetic stability of molecular assemblies.

Journal of the American Chemical Society (2004-02-05)
Amesh B Patel, Stephanie Allen, Martyn C Davies, Clive J Roberts, Saul J B Tendler, Philip M Williams
要旨

The strength of a multimolecular system depends on the number of interactions that hold it together. Using dynamic force spectroscopy, we show how the kinetic stability of a system decreases as the number of molecular bonds is increased, as predicted by theory. The data raise important considerations for experimental tests of bond strength and, as a paradigm, suggest both routes to and pitfalls in methods for computational simulation of molecular transitions, such as ligand binding and protein folding.

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2-イミノビオチン, ≥98% (TLC)