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Merck

Isolation and structure elucidation of new PKCalpha inhibitors from Pinus flexilis.

Journal of natural products (1998-12-03)
K K Lee, B D Bahler, G A Hofmann, M R Mattern, R K Johnson, D G Kingston
要旨

Bioassay-guided fractionation of the CH2Cl2-MeOH extract of Pinus flexilis using an assay for protein kinase C (PKC) inhibitory activity led to the isolation of the two new bioactive diarylheptanoids (3R)-1,7-bis(3, 4-dihydroxyphenyl)-3-(beta-D-glucopyranosyl)heptan-3-ol (1) and its aglycon (3R)-1,7-bis(3,4-dihydroxyphenyl)heptan-3-ol (2), together with the three known bioactive compounds, hirsutenone (3), oregonin (4), and hirsutanonol (5). The IC50 values of compounds 1-5 in the PKC assay were 1.4, 1.6, 1.4, 8.6, and 4.6 microg/mL, respectively.

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製品番号
ブランド
製品内容

Sigma-Aldrich
Oregonin, ≥95% (LC/MS-ELSD)