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Intergenerational effect of short-term spaceflight in mice.

iScience (2021-07-20)
Keisuke Yoshida, Shin-Ichiro Fujita, Ayako Isotani, Takashi Kudo, Satoru Takahashi, Masahito Ikawa, Dai Shiba, Masaki Shirakawa, Masafumi Muratani, Shunsuke Ishii
要旨

As space travel becomes more accessible, it is important to understand the effects of spaceflight including microgravity, cosmic radiation, and psychological stress. However, the effect on offspring has not been well studied in mammals. Here we investigated the effect of 35 days spaceflight on male germ cells. Male mice that had experienced spaceflight exhibit alterations in binding of transcription factor ATF7, a regulator of heterochromatin formation, on promoter regions in testis, as well as altered small RNA expression in spermatozoa. Offspring of space-traveling males exhibit elevated hepatic expression of genes related to DNA replication. These results indicate that spaceflight has intergenerational effect.

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ウシ血清アルブミン ウシ血清由来, heat shock fraction, pH 7, ≥98%
Sigma-Aldrich
プロテイナーゼ K from Tritirachium album, (from Tritirachium album) chromatographically purified lyophilized 30 mAnson-U/mg for biochemistry and molecular biology EC 3.4.21.14