- Photoredox-Catalyzed Hydroxymethylation of Heteroaromatic Bases.
Photoredox-Catalyzed Hydroxymethylation of Heteroaromatic Bases.
The Journal of organic chemistry (2016-06-18)
Chelsea A Huff, Ryan D Cohen, Kevin D Dykstra, Eric Streckfuss, Daniel A DiRocco, Shane W Krska
PMID27315015
要旨
We report the development of a method for room-temperature C-H hydroxymethylation of heteroarenes. A key enabling advance in this work was achieved by implementing visible light photoredox catalysis that proved to be applicable to many classes of heteroarenes and tolerant of diverse functional groups found in druglike molecules.
材料