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由来生物
rabbit
品質水準
100
500
結合体
unconjugated
抗体製品の状態
culture supernatant
抗体製品タイプ
primary antibodies
クローン
EPR3653, monoclonal
詳細
For In Vitro Diagnostic Use in Select Regions (See Chart)
形状
buffered aqueous solution
化学種の反応性
human
包装
vial of 0.1 mL concentrate (114R-14)
vial of 0.5 mL concentrate (114R-15)
bottle of 1.0 mL predilute (114R-17)
vial of 1.0 mL concentrate (114R-16)
bottle of 7.0 mL predilute (114R-18)
メーカー／製品名
Cell Marque™
テクニック
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200
アイソタイプ
IgG
コントロール
tonsil
輸送温度
wet ice
保管温度
2-8°C
視覚化
cytoplasmic, membranous
遺伝子情報
human ... CD14(929)
関連するカテゴリー
詳細
CD14 is a surface protein preferentially expressed on monocytes/macrophages. It binds lipopolysaccharide binding protein and recently has been shown to bind apoptotic cells. Anti-CD14 antibody labels Kupffer cells in liver sinusoids. In lymphoid tissues, dendritic cells are distinctly stained. Most other normal tissues are negative. This antibody labels monocyte-macrophages and Langerhans cells in Langerhans cell histiocytosis. Tumor cells are positive in monocytic leukemia and true histiocytic lymphomas for CD14. Sinusoidal histiocytes express CD14 and CD 169, whereas most of the other monocyte-derived cells in reactive lymph node lack these markers. Anti-CD14 labels numerous diffuse large B-cell lymphomas and splenic marginal zone lymphoma but not in other B-cell lymphomas.
品質
 IVD |  IVD |  IVD |  RUO |
関連事項
CD14 Positive Control Slides, Product No. 114S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
物理的形状
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
調製ノート
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
その他情報
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
法的情報
Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany
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試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
B Steiniger et al.
Immunology, 92(2), 307-316 (1998-01-01)
The microanatomical structure of human and rat splenic white pulp is compared, with special emphasis on the localization of the marginal zone occupied by immunoglobulin M (IgM)+ IgD-/dull B lymphocytes and its specialized macrophages. Our study reveals that in contrast
A T Larregina et al.
Nature immunology, 2(12), 1151-1158 (2001-11-10)
Epidermal Langerhans cells (LCs) show extraordinary immunostimulatory capacity and play a key role in the initiation and regulation of immune responses. Studies of LC biology are currently the focus of efforts to engineer immune responses and to better understand the
Béatrice Marmey et al.
Human pathology, 37(1), 68-77 (2005-12-20)
The mononuclear phagocyte system of human lymphoid tissue comprises macrophages and dendritic cells (DCs). The heterogeneity of the non-DC mononuclear phagocyte population in human lymphoid tissue has been little addressed. Here, we studied the expression of 2 monocyte-derived markers, CD14
P J Buckley et al.
The American journal of pathology, 128(3), 505-520 (1987-09-01)
Macrophages (M phi s) are an important component of the immune response and mediate numerous other functions. Phenotypic and functional subsets of circulating monocytes have been described, but few similar studies have analyzed M phi s in human tissues. By
H W Ziegler-Heitbrock et al.
Immunology today, 14(3), 121-125 (1993-03-01)
In the past, CD14 has been viewed simply as a useful marker molecule for monocytes and macrophages. Now, new findings on its role in binding of LPS-LBP complexes and in signal transduction have engendered renewed interest in the properties of
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