Skip to Content
Merck
All Photos(1)

Key Documents

Safety Information

1193265

USP

Diethylene glycol

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

2,2′-Oxydiethanol, 2-Hydroxyethyl ether, Bis(2-hydroxyethyl) ether, Diglycol

Sign Into View Organizational & Contract Pricing


About This Item

Linear Formula:
(HOCH2CH2)2O
CAS Number:
Molecular Weight:
106.12
Beilstein:
969209
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

vapor density

2.14 (vs air)

vapor pressure

0.01 mmHg ( 20 °C)

API family

diethylene glycol

autoignition temp.

442 °F

expl. lim.

2-12.3 %

manufacturer/tradename

USP

refractive index

n20/D 1.447 (lit.)

bp

245 °C (lit.)

mp

−10 °C (lit.)

density

1.118 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

OCCOCCO

InChI

1S/C4H10O3/c5-1-3-7-4-2-6/h5-6H,1-4H2

InChI key

MTHSVFCYNBDYFN-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Diethylene glycol USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Propylene Glycol
  • Glycerin
  • Polyoxyl 40 Hydrogenated Castor Oil
  • Sorbitol Solution
  • Polyethylene Glycol 3350
  • Maltitol Solution
  • Noncrystallizing Sorbitol Solution

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

related product

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

280.4 °F - closed cup

Flash Point(C)

138 °C - closed cup


Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

FSL

Group 4: Flammable liquids
Type 3 petroleums
Hazardous rank III
Water soluble liquid

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

1193265:
1193265-0.5ML:
1193265-5X0.2ML:


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Glycerin
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 28(4), 2123-2123 (2020)
Nestor R Sosa et al.
Annals of emergency medicine, 64(1), 38-47 (2014-01-21)
Diethylene glycol is a toxic industrial solvent responsible for more than 13 mass poisonings since 1937. Little is known about the clinical spectrum, progression, and neurotoxic potential of diethylene glycol-associated disease because of its high mortality and the absence of
Joshua G Schier et al.
Journal of public health policy, 30(2), 127-143 (2009-07-15)
Diethylene glycol (DEG), an extremely toxic chemical, has been implicated as the etiologic agent in at least 12 medication-associated mass poisonings over the last 70 years. Why DEG mass poisonings occur remains unclear. Most reports do not contain detailed reports
Leo J Schep et al.
Clinical toxicology (Philadelphia, Pa.), 47(6), 525-535 (2009-07-10)
Diethylene glycol (DEG) is a clear, colorless, practically odorless, viscous, hygroscopic liquid with a sweetish taste. In addition to its use in a wide range of industrial products, it has also been involved in a number of prominent mass poisonings
J L Hébert et al.
La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 59(5), 344-349 (1983-02-03)
Although acute poisoning with ethylene glycol (EG) used in antifreeze mixtures is well known in man, only a few reports have described acute intoxication with diethylene glycol (DEG) and only one has mentioned oxaluria. Furthermore, there is no experimental evidence

Protocols

99%; Glycerol, ≥99.5%; Tetraethylene glycol, 99%

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service