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Safety Information

W103

Sigma-Aldrich

WIN 51708 hydrate

solid

Synonym(s):

17-β-Hydroxy-17-α-ethynyl-5-α-androstano[3,2-β]pyrimido[1,2-α]benzimidazole

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About This Item

Empirical Formula (Hill Notation):
C29H33N3O · xH2O
CAS Number:
144177-30-0
Molecular Weight:
439.59 (anhydrous basis)
MDL number:
MFCD11045993
UNSPSC Code:
12352200
PubChem Substance ID:
24900776
NACRES:
NA.77

form

solid

Quality Level

100

color

yellow

solubility

DMSO: >10 mg/mL
H2O: insoluble

storage temp.

−20°C

SMILES string

O.C[C@]12Cc3cn4c(nc3C[C@@H]1CC[C@@H]5[C@@H]2CC[C@@]6(C)[C@H]5CC[C@@]6(O)C#C)nc7ccccc47

InChI

1S/C29H33N3O.H2O/c1-4-29(33)14-12-22-20-10-9-19-15-24-18(16-27(19,2)21(20)11-13-28(22,29)3)17-32-25-8-6-5-7-23(25)30-26(32)31-24;/h1,5-8,17,19-22,33H,9-16H2,2-3H3;1H2/t19-,20+,21-,22-,27-,28-,29-;/m0./s1

InChI key

RGVGINOANKXLLR-GCGDSGHKSA-N

Gene Information

rat ... Tacr1(24807)

Biochem/physiol Actions

WIN 51708 hydrate is a non-peptide NK1 tachykinin receptor antagonist.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

W103-25MG:
W103-100MG:
W103-BULK:
W103-5MG:
W103-VAR:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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B R Venepalli et al.
Journal of medicinal chemistry, 35(2), 374-378 (1992-01-24)
Several heterosteroids containing a dihydroethisterone skeleton were prepared and shown to displace substance P in a receptor binding assay. Further biochemical (kinetic and Scatchard analyses) and pharmacological evaluation (substance P-induced plasma extravasation and salivation in the rat) of a representative
K C Appell et al.
Molecular pharmacology, 41(4), 772-778 (1992-04-01)
125I-Bolton-Hunter-substance P (125I-BH-SP) binding properties of three novel classes of neurokinin-1 (NK-1) receptor antagonists were investigated in tissues derived from humans, guinea pigs, and rats. 125I-BH-SP was shown to bind to a single class of binding sites, with similar dissociation

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