Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

Safety Information

D5943

Sigma-Aldrich

2-(3,4-Dimethoxy-benzoylamino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid amide

≥98% (HPLC), solid

Synonym(s):

Flt-3 inhibitor

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C18H20N2O4S
CAS Number:
301305-73-7
Molecular Weight:
360.43
MDL number:
MFCD00617269
UNSPSC Code:
12352106
PubChem Substance ID:
24724465
NACRES:
NA.77

Assay

≥98% (HPLC)

form

solid

storage condition

protect from light
under inert gas

color

white to off-white

solubility

H2O: <2 mg/mL
DMSO: ~8 mg/mL

storage temp.

−20°C

SMILES string

COc1ccc(cc1OC)C(=O)Nc2sc3CCCCc3c2C(N)=O

InChI

1S/C18H20N2O4S/c1-23-12-8-7-10(9-13(12)24-2)17(22)20-18-15(16(19)21)11-5-3-4-6-14(11)25-18/h7-9H,3-6H2,1-2H3,(H2,19,21)(H,20,22)

InChI key

FSPQCTGGIANIJZ-UHFFFAOYSA-N

Biochem/physiol Actions

Flt-3 (fms-related tyrosine kinase 3) inhibitor

Features and Benefits

This compound is featured on the PDGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

D5943-25MG:
D5943-BULK:
D5943-5MG:
D5943-VAR:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Raymond J Patch et al.
Bioorganic & medicinal chemistry letters, 16(12), 3282-3286 (2006-04-04)
A series of 2-acylaminothiophene-3-carboxamides has been identified which exhibit potent inhibitory activity against the FLT3 tyrosine kinase. Compound 44 inhibits the isolated enzyme (IC50 = 0.027 microM) and blocks the proliferation of MV4-11 cells (IC50 = 0.41 microM). Structure-activity relationship

Articles

PDGFR

Sigma-Aldrich offers many products related to PDGFR for your research needs.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service