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Safety Information

SML2749

Sigma-Aldrich

iFSP1

≥98% (HPLC)

Synonym(s):

1-Amino-3-(4-methylphenyl)pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile, 1-Amino-3-(p-tolyl)benzo[4,5]imidazo[1,2-a]pyridine-2,4-dicarbonitrile, 1-Amino-3-p-tolyl-benzo[4,5]imidazo[1,2-a]pyridine-2,4-dicarbonitrile

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About This Item

Empirical Formula (Hill Notation):
C20H13N5
CAS Number:
150651-39-1
Molecular Weight:
323.35
MDL number:
MFCD01572665
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

NC1=C(C#N)C(C2=CC=C(C)C=C2)=C(C#N)C3=NC4=C(C=CC=C4)N31

Biochem/physiol Actions

iFSP1 is a potent selective inhibitor of ferroptosis-suppressor-protein 1 (FSP1) that induces ferroptosis in cancer cells. iFSP1 strongly synergizes with GPX4 inhibitors to initiate ferroptosis in cancer cells.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PDSCL

Deleterious substance

JAN Code

SML2749-VAR:
SML2749-25MG:
SML2749-5MG:
SML2749-BULK:

Certificates of Analysis (COA)

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Sebastian Doll et al.
Nature, 575(7784), 693-698 (2019-10-22)
Ferroptosis is an iron-dependent form of necrotic cell death marked by oxidative damage to phospholipids1,2. To date, ferroptosis has been thought to be controlled only by the phospholipid hydroperoxide-reducing enzyme glutathione peroxidase 4 (GPX4)3,4 and radical-trapping antioxidants5,6. However, elucidation of

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