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Safety Information

SML2525

Sigma-Aldrich

Tafluprost

≥98% (HPLC)

Synonym(s):

(5Z)-7-[(1R,2R,3R,5S)-2-[(1E)-3,3-Difluoro-4-phenoxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl]-5-heptenoic acid 1-methylethyl ester, 16-phenoxy-15-deoxy-15,15-difluoro-17,18,19,20-tetranorprostaglandin F2α isopropyl ester, AFP-168

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About This Item

Empirical Formula (Hill Notation):
C25H34F2O5
CAS Number:
209860-87-7
Molecular Weight:
452.53
MDL number:
MFCD08062150
UNSPSC Code:
51111800
NACRES:
NA.77

Assay

≥98% (HPLC)

form

oil

optical activity

[α]/D +20 to +25°, c = 1 in chloroform-d

color

colorless to yellow

storage temp.

−20°C

InChI

1S/C25H34F2O5/c1-18(2)32-24(30)13-9-4-3-8-12-20-21(23(29)16-22(20)28)14-15-25(26,27)17-31-19-10-6-5-7-11-19/h3,5-8,10-11,14-15,18,20-23,28-29H,4,9,12-13,16-17H2,1-2H3/b8-3+,15-14+

InChI key

WSNODXPBBALQOF-ZHDUIJGQSA-N

Biochem/physiol Actions

Taflupost is a prostaglandin F2α agonist that lowers intraocular pressure and is used in the treatment of glaucoma. It has high affinity and selectivity for the fluoroprostaglandin (FP) receptor PGF2α. Tafluprost is believed to reduce the intraocular pressure (IOP) by increasing the outflow of aqueous humor. Tafluprost is a pro-drug. The active metabolite is the free acid.

Pictograms

Health hazard
GHS08

Signal Word

Warning

Hazard Statements

H361d

Hazard Classifications

Repr. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML2525-25MG:
SML2525-BULK:
SML2525-5MG:
SML2525-VAR:

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