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Safety Information

SML1506

Sigma-Aldrich

KY-05009

≥98% (HPLC)

Synonym(s):

5-(4-Methylbenzamido)-2-(phenylamino)thiazole-4-carboxamide, 5-[(4-Methylbenzoyl)amino]-2-(phenylamino)-4-thiazolecarboxamide

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About This Item

Empirical Formula (Hill Notation):
C18H16N4O2S
CAS Number:
1228280-29-2
Molecular Weight:
352.41
UNSPSC Code:
12352200
PubChem Substance ID:
329825926
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

light yellow to dark yellow

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

NC(C1=C(NC(C2=CC=C(C)C=C2)=O)SC(NC3=CC=CC=C3)=N1)=O

InChI

1S/C18H16N4O2S/c1-11-7-9-12(10-8-11)16(24)22-17-14(15(19)23)21-18(25-17)20-13-5-3-2-4-6-13/h2-10H,1H3,(H2,19,23)(H,20,21)(H,22,24)

InChI key

WCEDGRTWDSHZHF-UHFFFAOYSA-N

Biochem/physiol Actions

KY-05009 is a Traf2- and Nck-interacting kinase (TNIK) inhibitor that inhibits the epithelial-to-mesenchymal transition (EMT) in cancer cells.
KY-05009 is also known as (5-(4-methylbenzamido)-2-(phenylamino) thiazole-4-carboxamide). It prevents the proliferation induced by interleukin-6 and promotes cell death by blocking Wnt signaling in multiple myeloma (MM) cells. KY-05009 is a novel aminothiazole, which possesses anti-cancer activity in human colorectal cancer cells. KY-05009 prevents migration and invasion stimulated by TGF-β1 (transforming growth factor beta 1).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML1506-25MG:
SML1506-BULK:
SML1506-VAR:
SML1506-5MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Synergistic inhibition effect of TNIK inhibitor KY-05009 and receptor tyrosine kinase inhibitor dovitinib on IL-6-induced proliferation and Wnt signaling pathway in human multiple myeloma cells
Lee Y, et al.
Oncotarget, 8(25), 41091-41091 (2017)

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