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Safety Information

SML0688

Sigma-Aldrich

PO1

≥98% (HPLC)

Synonym(s):

2′,3′,6′,7′-Tetrahydro-12′-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-Spiro[isobenzofuran-1(3H)

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About This Item

Empirical Formula (Hill Notation):
C32H32BNO5
CAS Number:
1199576-10-7
Molecular Weight:
521.41
UNSPSC Code:
12352200
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

faintly pink to red

solubility

DMSO: 1 mg/mL, clear (warmed)

storage temp.

2-8°C

InChI

1S/C32H32BNO5/c1-30(2)31(3,4)39-33(38-30)20-13-14-24-26(18-20)36-28-22-11-8-16-34-15-7-9-19(27(22)34)17-25(28)32(24)23-12-6-5-10-21(23)29(35)37-32/h5-6,10,12-14,17-18H,7-9,11,15-16H2,1-4H3

InChI key

KNTNXZHHCPNNGB-UHFFFAOYSA-N

General description

Peroxy orange 1 (PO1) is a H2O2-specific fluorescent probe. PO1 probe is non-trappable and highly permeable in nature.

Application

Peroxy orange 1 (PO1) has been used to detect H2O2 in RtSS (root to shoot silencing) and wild-type Columbia and in rci3-1 and rci3-2 mutants.

Biochem/physiol Actions

PO-1 is a cell-permeable fluorescent sensor that is highly selective for detecting the presence of H2O2 in living cells.

Legal Information

This product may be used for research purposes only. It is not licensed for resale and may only be used by the buyer. This product may not be used and is not licensed for clinical assays, where the results of such assays are provided as a diagnostic service. If a diagnostic or therapeutic use is anticipated, then a license must be requested from the University of California. The availability of such diagnostic and therapeutic use license(s) cannot be guaranteed from the University of California.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PRTR

Class I Designated Chemical Substances

JAN Code

SML0688-VAR:
SML0688-5MG:
SML0688-BULK:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Boronate-Based Fluorescent Probes: Imaging Hydrogen Peroxide in Living Systems
Lin V S, et al.
Methods in Enzymology, 526, 19-43 (2013)
Mobile gene silencing in Arabidopsis is regulated by hydrogen peroxide
Liang D, et al.
PeerJ, 2, e701-e701 (2014)
Sandeep Saxena et al.
Nature communications, 10(1), 4400-4400 (2019-09-29)
A surveillance system in mammals constantly monitors cell activity to protect against aberrant proliferation in response to damage, injury and oncogenic stress. Here we isolate and culture connective tissue fibroblasts from highly regenerative mammals (Acomys and Oryctolagus) to determine how

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