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Safety Information

SAE0022

Sigma-Aldrich

Phosphoglucomutase 1 human

lyophilized powder, recombinant, expressed in E. coli

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About This Item

Enzyme Commission number:
5.4.2.2 (BRENDA, IUBMB)
UNSPSC Code:
12352204
NACRES:
NA.54

recombinant

expressed in E. coli

Quality Level

200

description

PGM1 isoform sequence with a predicted molecular mass of 61.3kDa.

Assay

≥95% (PAGE)

form

lyophilized powder

specific activity

≥400 units/mg protein

shipped in

dry ice

storage temp.

−20°C

General description

Phosphoglucomutase-1 (PGM1) is an evolutionarily conserved enzyme that belongs to the phosphohexose mutase family. It is the major isoform of PGM in skeletal muscle and most other tissues. The PGM1 gene is mapped to human chromosome 1p31.3.

Biochem/physiol Actions

Phosphoglucomutase-1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P). It regulates carbohydrate metabolism, energy production, and protein N-glycosylation. PGM1 participates in the biosynthesis of nucleotide sugars required for glycan biosynthesis. Variation in the PGM1 gene leads to PGM1 deficiency, which is considered an inherited metabolic disorder in humans. PGM1 deficiency causes autosomal recessive diseases such as glycogen storage disease type XIV and congenital disorder of protein N-glycosylation. Affected patients show multiple disease phenotypes, reflecting the central role of the enzyme in glucose homeostasis. The influence of PGM1 deficiency on protein glycosylation patterns is also widespread. PGM1 acts as a metabolic tumor suppressor.

Unit Definition

One unit will convert 1.0 μmole of α-D-Glucose-1-Phosphate to α-D-Glucose-6-phosphate per minute at pH 7.4 at 30 °C.

Physical form

Supplied as a lyophilized powder containing tris-buffered saline, EDTA, DTT and stabilizer.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SAE0022-VAR:
S0191-25MG:
SAE0022-1MG:
SAE0022-1MG-PW:
SAE0022-BULK:

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Certificates of Analysis (COA)

Lot/Batch Number
035M4035V
11150303

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Paul Hoff Backe et al.
Scientific reports, 10(1), 5656-5656 (2020-03-30)
Human phosphoglucomutase 1 (PGM1) is an evolutionary conserved enzyme that belongs to the ubiquitous and ancient α-D-phosphohexomutases, a large enzyme superfamily with members in all three domains of life. PGM1 catalyzes the bi-directional interconversion between α-D-glucose 1-phosphate (G1P) and α-D-glucose
Eva Morava
Molecular genetics and metabolism, 112(4), 275-279 (2014-07-07)
We recently redefined phosphoglucomutase-1 deficiency not only as an enzyme defect, involved in normal glycogen metabolism, but also an inborn error of protein glycosylation. Phosphoglucomutase-1 is a key enzyme in glycolysis and glycogenesis by catalyzing in the bidirectional transfer of
Guang-Zhi Jin et al.
PLoS biology, 16(10), e2006483-e2006483 (2018-10-20)
Glycogen metabolism commonly altered in cancer is just beginning to be understood. Phosphoglucomutase 1 (PGM1), the first enzyme in glycogenesis that catalyzes the reversible conversion between glucose 1-phosphate (G-1-P) and glucose 6-phosphate (G-6-P), participates in both the breakdown and synthesis

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