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Key Documents

Safety Information

SAB5500165

Sigma-Aldrich

Anti-Progesterone Receptor antibody, Rabbit monoclonal

recombinant, expressed in proprietary host, clone SP2, tissue culture supernatant

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

recombinant

expressed in proprietary host

conjugate

unconjugated

antibody form

tissue culture supernatant

antibody product type

primary antibodies

clone

SP2, monoclonal

species reactivity

human (tested)

species reactivity (predicted by homology)

bovine, rabbit, pig

technique(s)

immunohistochemistry: 1:400

isotype

IgG

UniProt accession no.

P06401

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

human ... PGR(5241)

General description

The progesterone receptor (PgR) is an estrogen-regulated protein. It has been proposed that expression of PgR determination indicates a responsive estrogen receptor (ER) pathway. A number of studies have shown that PgR determination provides supplementary information to ER.
Progesterone receptor (PGR) belongs to the steroid/thyroid hormone receptor family of ligand-activated transcription factors. It possesses the amino-terminal AF1 region, the central DNA-binding domain (DBD) and the carboxyl-terminal ligand- binding domain (LBD). The PGR gene is localized on human chromosome 11q22.1.

Immunogen

Recombinant protein encoding aa 412-526 of human progesterone receptor.

Biochem/physiol Actions

Progesterone receptor (PGR) functions as a transcription factor,
which modulates the transcription of target genes in response to progesterone and other hormones. It is phosphorylated on multiple sites and at times, the phosphorylation changes according to the hormone involved. During hormone unavailability, PGR is bound to heat shock proteins. When the ligand binds, it causes the release of PGR from heat shock proteins. It is then translocated to the nucleus, where it binds to its DNA response elements (SREs) and to the components of the transcription machinery. PGR also binds to chromatin templates and results in chromatin remodeling adjacent to the PGR-binding sites.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

0.1 ml rabbit monoclonal antibody supplied as tissue culture supernatant in TBS/1% BSA buffer pH 7.5 with less than 0.1% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SAB5500165-100UL:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Jake J Reske et al.
Human molecular genetics, 29(20), 3412-3430 (2020-10-20)
Although ARID1A mutations are a hallmark feature, mutations in other SWI/SNF (SWItch/Sucrose Non-Fermentable) chromatin remodeling subunits are also observed in endometrial neoplasms. Here, we interrogated the roles of Brahma/SWI2-related gene 1 (BRG1, SMARCA4), the SWI/SNF catalytic subunit, in the endometrial
Steroid receptor coactivator-1 (SRC-1) enhances ligand-dependent and receptor-dependent cell-free transcription of chromatin.
Liu Z, et al.
Proceedings of the National Academy of Sciences of the USA, 96(17), 9485-9490 (1999)
Olivia Jeong et al.
International journal of molecular sciences, 23(23) (2022-12-12)
Women with complex atypical hyperplasia (CAH) or early-stage endometrioid endometrial cancer (EEC) are candidates for fertility preservation. The most common approach is progesterone (P4) therapy and deferral of hysterectomy until after completion of childbearing. However, P4 therapy response rates vary
Phosphorylation of human progesterone receptor by cyclin-dependent kinase 2 on three sites that are authentic basal phosphorylation sites in vivo.
Zhang Y, et al.
Molecular Endocrinology, 11(6), 823-832 (1997)
Phosphorylation of human progesterone receptor by cyclin-dependent kinase 2 on three sites that are authentic basal phosphorylation sites in vivo.
Y Zhang
Molecular Endocrinology, 11(6), 823-832 (1997)
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