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S4521

Sigma-Aldrich

Saponin from Quillaja sp.

Sapogenin content 20-35 %

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About This Item

CAS Number:
8047-15-2
EC Number:
232-462-6
MDL number:
MFCD00081981
UNSPSC Code:
12161902
NACRES:
NA.32

description

non-ionic

Quality Level

300

composition

Sapogenin content, 20-35%

technique(s)

HPLC: suitable
protein quantification: suitable

sulfated ash

≤10%

General description

Saponins are steroid or triterpenoid glycosides. They are biosurfactants that have several uses in the food and cosmetic industry.

Application

Saponin from Quillaja bark has been used:
  • to stain fertilized oocytes
  • in the analysis of intracellular cytokine production
  • to permeabilize dendritic cells

Biochem/physiol Actions

Saponins solubilize the low density lipoprotein (LDL) fraction of cholesterol in micelles, thus lowering their concentration. Saponin from Quillaja bark is used as a flavoring agent in food and beverages. This saponin has been shown to enhance immune-cell proliferation in vitro.
Potent hemolytic when injected i.v.; surfactant that enhances penetration of proteins and other macromolecules through cell membranes; it also has been used as an adjuvant for vaccines.

Preparation Note

Purified to remove low molecular weight contaminants 

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H319,H335

Hazard Classifications

Eye Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

S4521-VAR:
S4521-BULK:
S4521-25G:
S4521-10G:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Subset-dependent modulation of dendritic cell activity by circovirus type 2.
Vincent IE
Immunology, 115(3), 388-398 (2005)
Isolation of myeloid and plasmacytoid dendritic cells from human bronchoalveolar lavage fluid.
Tsoumakidou M
Immunology and Cell Biology, 84(3), 267-273 (2006)
Dynamic chromatin modifications characterise the first cell cycle in mouse embryos.
Santos F
Developmental Biology, 280(1), 225-236 (2005)
Yvonne Lange et al.
Biochemistry, 48(36), 8505-8515 (2009-08-07)
A few membrane-intercalating amphipaths have been observed to stimulate the interaction of cholesterol with cholesterol oxidase, saponin and cyclodextrin, presumably by displacing cholesterol laterally from its phospholipid complexes. We now report that this effect, referred to as cholesterol activation, occurs
Adjuvant effects of saponins on animal immune responses.
Rajput ZI
Journal of Zhejiang University. Science. B, 8(3), 153-161 (2007)
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