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Safety Information

R2156

Sigma-Aldrich

Relaxin-1 human

recombinant, expressed in E. coli, >95% (SDS-PAGE), lyophilized powder

Synonym(s):

RLN1, RLXH1, Relaxin 1

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About This Item

CAS Number:
2222237-37-6
UNSPSC Code:
12352202
NACRES:
NA.26

biological source

human

Quality Level

100

recombinant

expressed in E. coli

Assay

>95% (SDS-PAGE)

form

lyophilized powder

mol wt

(Contains two disulfide-linked subunits: A chain ~2.8 kDa B chain ~3.3 kDa)

technique(s)

cell culture | mammalian: suitable

suitability

endotoxin tested

UniProt accession no.

P04808

storage temp.

−20°C

Gene Information

human ... RLN1(6013)

General description

Cell signaling hormone that is prominent in the prostate, and belongs to the insulin superfamily

Biochem/physiol Actions

Relaxin 1 may function in regulating blood pressure, controlling heart rate, and releasing oxytocin and vasopressin
Relaxin has been shown to have antifibrotic effects in renal fibroblasts through mechanisms that increase collagenase activity and via TGF-β signaling.

Physical form

Lyophilized powder containing BSA

Reconstitution

In Phosphate buffered saline solution containing at least 0.1% serum albumin. The concentration should be ≥10 μg/mL

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

R2156-BULK:
R2156-25UG:
R2156-VAR:
R2156-25UG-PW:

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Certificates of Analysis (COA)

Lot/Batch Number
MKCP5352
MKCM4370
MKCD2730
MKCC9494
MKCB2764V

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Rosemary Masterson et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 19(3), 544-552 (2004-02-10)
Renal fibroblasts are important effector cells in tubulointerstitial fibrosis, with experimental antifibrotic strategies focusing on the functional down-regulation of these cells. Several experimental models of fibrosis have provided evidence for the effectiveness of the polypeptide hormone relaxin as a potential

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