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Safety Information

R0775

Sigma-Aldrich

RANK/Fc Chimera from mouse

≥95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture

Synonym(s):

Osteoclast differentiation receptor, ODFR, Receptor activator of NF-κB

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About This Item

MDL number:
MFCD03703131
UNSPSC Code:
51111800
NACRES:
NA.32

biological source

mouse

Quality Level

200

recombinant

expressed in NSO cells

Assay

≥95% (SDS-PAGE)

form

lyophilized powder

potency

10.12 μg/mL EC50

mol wt

60 kDa

packaging

pkg of 1 mg

storage condition

avoid repeated freeze/thaw cycles

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

UniProt accession no.

O35305

storage temp.

−20°C

Gene Information

mouse ... Tnfrsf11a(21934)

Application

RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis. The biological functions mediated by RANK include activation of NF-ΚB and c-jun N-terminal kinase, enhancement of T cell growth and dendritic cell function, induction of osteoclastogenesis and lymph node organogenesis.

Biochem/physiol Actions

TRANCE (TNF-related activation-induced cytokines, also known as RANK ligand, osteoprotegerin ligand and osteoclast differentiation factor) is the ligand for RANK. The biological functions mediated through RANK include activation of NF-κB and c-jun N-terminal kinases, enhancement of T cell growth and dentritic cell function, induction of osteoclastogenesis, and lymph node genesis. Soluble RANK is able to block TRANCE-induced biological activity.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Analysis Note

The biological activity is measured by its ability to inhibit TRANCE-induced osteoclast differentiation in mouse splenocytes.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

R0775-.1MG-PW:
R0775-.1MG:
R0775-VAR:
R0775-BULK:

Certificates of Analysis (COA)

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N Nakagawa et al.
Biochemical and biophysical research communications, 253(2), 395-400 (1999-01-08)
Osteoclast differentiation factor (ODF) is a ligand for osteoclastogenesis-inhibitory factor/osteoprotegerin (OCIF/OPG), and mediates an essential signal for osteoclastogenesis. Soluble-form ODF binds directly to osteoclast progenitors, suggesting the presence of a membrane-bound receptor for ODF (ODFR) on the cells. To understand
D M Anderson et al.
Nature, 390(6656), 175-179 (1997-11-21)
Dendritic cells are rare haematopoietic cells that reside in a number of organs and tissues. By capturing, processing and presenting antigens to T cells, dendritic cells are essential for immune surveillance and the regulation of specific immunity. Several members of

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