Merck
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P7556

Sigma-Aldrich

Progesterone-Water Soluble

powder, BioReagent, suitable for cell culture

Synonym(s):
Progesterone: HBC complex, Progesterone: methyl-β-cyclodextrin complex
MDL number:
PubChem Substance ID:
NACRES:
NA.77

biological source

synthetic (organic)

Quality Level

product line

BioReagent

assay

≥65% (HPLC)

form

powder

technique(s)

cell culture | mammalian: suitable

solubility

H2O: 25 mg/mL, clear to slightly hazy

shipped in

ambient

storage temp.

room temp

SMILES string

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@H](CC[C@@]24[H])C(C)=O

InChI

1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1

InChI key

RJKFOVLPORLFTN-LEKSSAKUSA-N

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General description

Progesterone is a steroid hormone secreted by the ovaries.[26]

Application

Progesterone-Water Soluble has been used:
  • for in vitro maturation of oocyte complexes
[28]
  • as a σ1R antagonist to study its effect on sigma 1 receptor
  • [29]
  • to study its effect on the differentiation of human multipotent mesenchymal stromal cells (hMSCs) in vitro
  • [30]
    This product is not recommended for use in binding assays.

    Packaging

    100 mg in glass bottle
    Package size based on progesterone content

    Biochem/physiol Actions

    Progesterone is a hormone that maintains pregnancy. It is essential for embryo formation, development and survival in almost all mammals. This hormone exhibits its action via progesterone receptor, which is specifically expressed in the endometrial stroma throughout pregnancy.[98] It is known to prevent preterm delivery, when administered intramuscularly.[99] Progesterone also controls gonadotropin secretion, activates sexual behavior and triggers ovarian events leading to ovulation. It stimulates the growth and differentiation of the uterus and prevents uterine contractility.[33]

    Other Notes

    Contains approx. 70 mg progesterone per gram; balance methyl-β-cyclodextrin.

    Pictograms

    Health hazard

    Signal Word

    Danger

    Hazard Statements

    Hazard Classifications

    Carc. 2 - Lact. - Repr. 1A

    Storage Class Code

    6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

    WGK

    WGK 3

    Flash Point(F)

    Not applicable

    Flash Point(C)

    Not applicable

    Certificate of Analysis

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    Certificate of Origin

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