Skip to Content
Merck
All Photos(1)

Key Documents

Safety Information

N6803

Sigma-Aldrich

Nystatin water soluble

powder, suitable for cell culture

Synonym(s):

Nystatin Solution

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

UNSPSC Code:
12352207
NACRES:
NA.76

product name

Nystatin water soluble, suitable for cell culture

biological source

synthetic

form

powder

mol wt

1029.23 g/mol

technique(s)

cell culture | mammalian: suitable

solubility

100 mg/mL

shipped in

dry ice

storage temp.

−20°C

Related Categories

General description

Nystatin is a polyene, broad-spectrum antibiotic. It can modify the microstructure of lipid rafts and sequestrate cholesterol present on the cell membrane of eukaryotes. Thus, nystatin can modulate immune responses. This is carried out through cytokine signaling, activation of lymphocytes and pathogen recognition.
Molecular Formula: C51H84N2O19
Molecular Weight: 1029.23
Nystatin water soluble is a Nystatin derivate with fungistatic and fungicidal activity in resemblance to Nystatin. However, as opposed to the poor solubility of Nystatin the water soluble derivate can be dissolved in concentration of up to 100mg/ml. Nystatin binds to ergosterol which increases cell membrane permeability in sensitive fungi. Nystatin is mainly clinically active against Candida species. However, it is also reported to be effective against Aspergillus, Coccidioides immitis, Cryptococcus neoformans, Histoplasma capsulatum, Blastomyces dermatidis, and other yeasts and fungi. Nystatin has also been used to enrich mutants by negative selection in yeasts. The minimum inhibitory concentration (MIC) of Nystatin to Saccharomyces cerevisiae was reported to be 3μg/ml while for clinical isolates of Candida albicans the MIC was reported to be 4-16μg/ml.

Other Notes

Technical data

  • Nystatin water soluble is a fully solubilized powder of Nystatin with potency of ≥2000 units/mg according to USP standard.
  • Nystatin water soluble is 0.2μm filtered and endotoxin free.
  • The suggest working concentration of Nystatin water soluble is 100 units/ml.
  • It is recommended to store solutions of Nystatin water soluble in the dark.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

N6803-5MG:
N6803-BULK:
N6803-VAR:
N6803-50MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Water-Soluble Nystatin and Derivative
Aviran Amir, Michal Levin-Khalifa, and Tamar Dvash
ACS Medicinal Chemistry Letters, 182?187-182?187 (2022)
Nystatin enhances the immune response against Candida albicans and protects the ultrastructure of the vaginal epithelium in a rat model of vulvovaginal candidiasis
Zhang X, et al.
BMC Microbiology, 18(1), 166-166 (2018)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service