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Safety Information

N3536

Sigma-Aldrich

Neuraminidase 5X Reaction Buffer

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About This Item

UNSPSC Code:
12352204

form

liquid

Quality Level

200

storage temp.

2-8°C

Application

Neuraminidase is a glycoside hydrolase enzyme that is involved in the spread of the influenza virus. It is used to research potential drugs, such as neuraminidase inhibitors, to treat influenza. Neuraminidase mutations are studied for their implications on influenza drug resistance .

Biochem/physiol Actions

Neuraminidase cleaves the glycosidic linkages of neuraminic acids. Neuraminidase aids in the dispersment of the flu virus in mucosal secretions of the respiratory tract. It also prevents virions from self-aggregation .

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

N3536-PH:
N3536-1.5ML-PW:
N3536-BULK:
N3536PROC:
N3536-1.5ML:
N3536-1.5ML-KC:
N3536-1VL:
N3536-150VL:
N3536-VAR:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Larisa V Gubareva
Virus research, 103(1-2), 199-203 (2004-05-28)
A wide use of inhibitors of influenza virus neuraminidase (NAIs) to control influenza in humans demands a better understanding of the mechanisms involved in the resistance emergence. In vitro studies demonstrate that both neuraminidase (NA) and hemagglutinin (HA) influence virus
In vitro passaging of a pandemic H1N1/09 virus selects for viruses with neuraminidase mutations conferring high-level resistance to oseltamivir and peramivir, but not to zanamivir
Jennifer L. McKimm-Breschkin, et al.
The Journal of Antimicrobial Chemotherapy, 10.1093, 150-150 (2012)

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