M2946

Mosapride citrate salt dihydrate

≥98% (HPLC), solid, 5-HT₄ receptor agonist

• Synonym(s): 4-Amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl ]-2-morpholinyl]methyl]benzamide citrate dihydrate
• Empirical Formula (Hill Notation): C₂₁H₂₅ClFN₃O₃ · C₆H₈O₇ · 2H₂O
• CAS Number: 636582-62-2
• Molecular Weight: 650.05
• MDL number: MFCD00874415
• UNSPSC Code: 12352200
• PubChem Substance ID: 329817957
• NACRES: NA.77

Properties

• product name: Mosapride citrate salt dihydrate,
• Assay: ≥98% (HPLC)
• form: solid
• solubility: DMSO: ≥5 mg/mL
• originator: Takeda
• storage temp.: 2-8°C
• SMILES string: O.O.OC(=O)CC(O)(CC(O)=O)C(O)=O.CCOc1cc(N)c(Cl)cc1C(=O)NCC2CN(CCO2)Cc3ccc(F)cc3
• InChI: 1S/C21H25ClFN3O3.C6H8O7.2H2O/c1-2-28-20-10-19(24)18(22)9-17(20)21(27)25-11-16-13-26(7-8-29-16)12-14-3-5-15(23)6-4-14;7-3(8)1-6(13,5(11)12)2-4(9)10;;/h3-6,9-10,16H,2,7-8,11-13,24H2,1H3,(H,25,27);13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);2*1H2
• InChI key: KVKIQHMTGSGTFO-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Mosapride is found effective against chronic gastritis, functional dyspepsia and gastro-oesophageal reflux disease. It is useful in treating many other symptoms associated with gastrointestinal disorders. Mosapride is known to improve digestive motility.

5-HT₄ receptor agonist and 5-HT₃ receptor antagonist

Features and Benefits

This compound was developed by Takeda. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Pictograms: GHS05
• Signal Word: Danger
• Hazard Statements: H318
• Precautionary Statements: P280 - P305 + P351 + P338
• Hazard Classifications: Eye Dam. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves