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Safety Information

H0786

Sigma-Aldrich

Heregulin-β, EGF Domain human

≥80% (SDS-PAGE), recombinant, expressed in E. coli, buffered aqueous glycerol solution

Synonym(s):

HRG-β

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About This Item

MDL number:
MFCD01867052
UNSPSC Code:
12352202
NACRES:
NA.32

biological source

human

Quality Level

200

recombinant

expressed in E. coli

Assay

≥80% (SDS-PAGE)

form

buffered aqueous glycerol solution

mol wt

185 kDa

packaging

pkg of 100 μg

storage condition

avoid repeated freeze/thaw cycles

UniProt accession no.

Q02297

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... NRG1(3084)

General description

Truncated human sequence (amino acids 178-241) corresponding to the EGF domain and purified as a GST-fusion protein, cleaved with thrombin.

Biochem/physiol Actions

Growth factor ligand for ErbB3 and ErbB4 receptor tyrosine kinases. The binding of HRG results in receptor dimerization and receptor trans-autophosphorylation. The phosphorylated receptors recruit cellular signaling proteins, initiating signaling pathways.

Physical form

Solution in phosphate buffered saline containing 30% glycerol.

Analysis Note

Stimulates tyrosine phosphorylation of the ErbB-3/HER-3 receptor.
The biological activity is measured by its ability to activate the c-ErbB3/HER-3 receptor in treated MCF-7 cells.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

H0786-50UG:
H0786-BULK:
H0786-100UG-PW:
H0786-VAR:
H0786-100UG:

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Certificates of Analysis (COA)

Lot/Batch Number
SLCM5158
SLCM5156
SLCM4991
SLCB1277
SLCB0110

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