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Key Documents

Safety Information

G5640

Sigma-Aldrich

Globulins Cohn fraction II, III from goat

Synonym(s):

Vitamin D binding protein

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About This Item

CAS Number:
68476-36-8
EC Number:
270-678-2
MDL number:
MFCD00164084
UNSPSC Code:
12352202
NACRES:
NA.61

biological source

goat

Quality Level

300

Assay

73-90% protein basis (biuret)

form

lyophilized powder

composition

Protein, 73-90% biuret

solubility

H2O: soluble 25 mg/mL

storage temp.

2-8°C

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General description

Vitamin D binding protein (DBP) is a polymorphic protein that specifically binds to vitamin D and its metabolites. This protein belongs to the albuminoid family and is highly conserved among vertebrates. The gene encoding DBP is mapped to human chromosome 4q11-q13. It is predominantly produced in the liver and is also expressed in the kidney, endocrine pancreatic cells, fat cells, and testis.

Application

Globulins were used in Biotin/avidin formulations.

Biochem/physiol Actions

Vitamin D binding protein (DBP) specifically binds and transports vitamin D and its metabolites with high affinity. It promotes fibrillar actin clearance by binding to actin monomers. DBP also binds to unsaturated fatty acids, megalin-cubilin receptor complex, the membrane of leukocytes, and the activation of the complement C5 system. The levels of DBP indicate the free concentration of all vitamin D metabolites. Decreased levels of serum DBP are observed in liver diseases, nephrotic syndrome, malnutrition, severe acute trauma, or disease.

Other Notes

Primarily γ-globulins

Physical form

Lyophilized powder containing NaCl

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

G5640-CP:
G5640PROC:
G5640-5G:
G5640-1G:
G5640-BULK:
G5640-VAR:

Certificates of Analysis (COA)

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