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E8399

Sigma-Aldrich

Eotaxin-3 human

>97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonym(s):

CCL26, SCYA26

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About This Item

MDL number:
MFCD01867165
UNSPSC Code:
12352202
NACRES:
NA.32

biological source

human

Quality Level

200

recombinant

expressed in E. coli

Assay

>97% (SDS-PAGE)

form

lyophilized powder

potency

0.25-1.0 mg

mol wt

~8.2 kDa

packaging

pkg of 25 μg

storage condition

avoid repeated freeze/thaw cycles

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

UniProt accession no.

Q9Y258

storage temp.

−20°C

Gene Information

human ... CCL26(10344)

General description

Eotaxin-3, also known as CCL26 or SCYA26, is a human CC chemokine and a functional ligand for CC chemokine receptor 3. This gene is localized to human chromosome 7q11.2, which codes for a protein of 71 amino acids. It belongs to the small inducible cytokine subfamily A , which also includes eotaxin and eotaxin-2.

Biochem/physiol Actions

Eotaxin-3 is a potent attractant of eosinophils, and might be responsible for the accumulation of eosinophils in atopic diseases. As it is involved in the recruitment of eosinophils in inflammatory diseases, it, along with its receptor, might have potential as therapeutic target in inflammatory disorders, such as asthma. Demethylation results in increased expression of this gene, which in turn influences allergic reactions. This gene is overexpressed in bullous pemphigoid (BP), which results in the accumulation of eosinophils in skin lesions, thus, contributing to the pathogenesis of BP. Its expression is also elevated in the active lesions of patients with ulcerative colitis (UC) and Crohn′s disease (CD). Thus, it might play a role in the pathogenesis of UC, where its major source is colonic myofibroblasts.
Eotaxin-3, also known as CCL26 or SCYA26, is a human CC chemokine and a functional ligand for CC chemokine receptor 3. Mature recombinant human eotaxin-3 has a molecular mass of approximately 8.2 kDa and demonstrates chemotactic activity for eosinophils.

Physical form

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% trifluoroacetic acid containing 1.25 mg bovine serum albumin.

Analysis Note

The biological activity is measured by its ability to induce chemotaxis of rat Y3 cells stably expressing hCCR3.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H319,H332

Hazard Classifications

Acute Tox. 4 Inhalation - Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

E8399-25UG-PW:
E8399-BULK:
E8399-25UG:4548173948881
E8399-VAR:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Eunjin Lim et al.
Journal of immunology (Baltimore, Md. : 1950), 192(1), 466-474 (2013-12-11)
DNA demethylation has been primarily studied in the context of development biology, cell fate, and cancer, with less attention on inflammation. In this article, we investigate the association between DNA methylation and production of the chemoattractant cytokine eotaxin-3 in the
M Kitaura et al.
The Journal of biological chemistry, 274(39), 27975-27980 (1999-09-17)
Previously, we mapped the novel CC chemokine myeloid progenitor inhibitory factor 2 (MPIF-2)/eotaxin-2 to chromosome 7q11.23 (Nomiyama, H., Osborne, L. R., Imai, T., Kusuda, J., Miura, R., Tsui, L.-C., and Yoshie, O. (1998) Genomics 49, 339-340). Since chemokine genes tend
C Günther et al.
Clinical and experimental immunology, 166(2), 145-153 (2011-10-12)
Eosinophils contribute to the pathogenesis of bullous pemphigoid (BP) by secretion of proinflammatory cytokines and proteases. Trafficking of eosinophils into tissue in animal models and asthma depends on interleukin-5 and a family of chemokines named eotaxins, comprising CCL11, CCL24 and
R F Guo et al.
Genomics, 58(3), 313-317 (1999-06-22)
By searching the Expressed Sequence Tag database, a full-length cDNA for a novel human CC chemokine was cloned. This cDNA encoded a 94-amino-acid protein with a putative signal peptide of 26 amino acids. The deduced mature protein had the four
A Shinkai et al.
Journal of immunology (Baltimore, Md. : 1950), 163(3), 1602-1610 (1999-07-22)
IL-4 has been shown to be involved in the accumulation of leukocytes, especially eosinophils, at sites of inflammation by acting on vascular endothelial cells. To identify novel molecules involved in the IL-4-dependent eosinophil extravasation, cDNA prepared from HUVEC stimulated with
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