Skip to Content
Merck
All Photos(1)

Key Documents

Safety Information

C9874

Sigma-Aldrich

Potassium clavulanate:cellulose (1:1)

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

UNSPSC Code:
51285005
NACRES:
NA.85

form

powder or crystals

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria

Mode of action

enzyme | inhibits

storage temp.

2-8°C

Application

Clavulanate is used as an inhibitor of bacterial β-lactamase enzymes. It is produced by the fermentation of Streptomyces clavuligerus. It has weak antibacterial activity when used alone but is very active when used with amoxicillin. With Amoxicillin, it is used to treat infections caused by Staph. aureus, Bacteroides fragilis, H. influenza and E. coli.. It has been used to treat acute bacterial sinusitis in children and chronic adenotonsillar hypertrophy.

Biochem/physiol Actions

Clavulanate is a β-lactam antibiotic related to the penicillins. Clavulanic acid competitively and irreversibly inhibits a wide variety of β-lactamases which are commonly found in microorganisms that are resistant to penicillins and cephalosporins. Clavulanate also is a modulator of the central nervous system. It enhances dopamine release in PC12 and SH-SY5Y cells without affecting dopamine synthesis.
Clavulanate is a β-lactamase inhibitor often used to enhance the antibacterial activity of amoxicillin.

Other Notes

Mixture of potassium clavulanate and cellulose
Keep container tightly closed in a dry and well-ventilated place. Never allow product to get in contact with water during storage.Heat sensitive. Storage class (TRGS 510): Flammable solid hazardous materials.

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H317,H334

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

Supplementary Hazards

EUH044

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

C9874-1G:
C9874-5G:
C9874-VAR:
C9874-BULK:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Slide 1 of 2

1 of 2

β-Lactamase recombinant, expressed in E. coli

Sigma-Aldrich

L6170

β-Lactamase

Meropenem trihydrate ≥98% (HPLC)

Sigma-Aldrich

M2574

Meropenem trihydrate

B Rossi et al.
Antimicrobial agents and chemotherapy, 60(1), 424-430 (2015-11-04)
We investigated the efficacies of cefotaxime (CTX) and amoxicillin (AMX)-clavulanate (CLA) (AMC) against extended-spectrum-β-lactamase (ESBL)-producing Escherichia coli in vitro and in a murine model of urinary tract infection (UTI). MICs, the checkerboard dilution method, and time-kill curves were used to
Ellen R Wald et al.
Pediatrics, 124(1), 9-15 (2009-07-01)
The role of antibiotic therapy in managing acute bacterial sinusitis (ABS) in children is controversial. The purpose of this study was to determine the effectiveness of high-dose amoxicillin/potassium clavulanate in the treatment of children diagnosed with ABS. This was a
Gina Chun Kost et al.
Neuroscience letters, 504(2), 170-175 (2011-10-04)
Clavulanic acid is a CNS-modulating compound with exceptional blood-brain barrier permeability and safety profile. Clavulanic acid has been proposed to have anti-depressant activity and is currently entering Phase IIb clinical trials for the treatment of Major Depressive Disorder (MDD). Studies
A P Sclafani et al.
Pediatrics, 101(4 Pt 1), 675-681 (1998-04-29)
To evaluate the short- and long-term effects of treatment of symptomatic chronic adenotonsillar hypertrophy (CATH) with a 30-day course of amoxicillin/clavulanate potassium (AMOX/CLAV). Children 2 to 16 years of age with obstructive symptoms attributable to CATH, who did not have
Alasdair M Geddes et al.
International journal of antimicrobial agents, 30 Suppl 2, S109-S112 (2007-09-29)
Infections are currently ranked as the leading global burden of disease with respiratory diseases playing the most significant role. Antibiotic resistance remains a serious problem, as it was even 50 years ago. The 1970s saw the introduction of a number
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service