33454

Potassium clavulanate

VETRANAL^®, analytical standard

• Synonym(s): Clavulanate potassium
• Empirical Formula (Hill Notation): C₈H₈NO₅K
• CAS Number: 61177-45-5
• Molecular Weight: 237.25
• EC Number: 262-640-9
• MDL number: MFCD01710901
• UNSPSC Code: 41116107
• PubChem Substance ID: 329754553
• NACRES: NA.24

Properties

• grade: analytical standard
• Quality Level: 200
• product line: VETRANAL^®
• shelf life: limited shelf life, expiry date on the label
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• application(s): agriculture; clinical; environmental; forensics and toxicology; pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-8°C
• SMILES string: [K+].[H][C@@]12CC(=O)N1[C@@H](C([O-])=O)C(\O2)=C\CO
• InChI: 1S/C8H9NO5.K/c10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4;/h1,6-7,10H,2-3H2,(H,12,13);/q;+1/p-1/b4-1-;/t6-,7-;/m1./s1
• InChI key: ABVRVIZBZKUTMK-JSYANWSFSA-M

Description

General description

Potassium clavulanate is an oxapenam derivative and belongs to the group of β-lactamase inhibitors. It is used in combination with the penicillin group of antibiotics to give them resistance to β-lactamase.

Application

The analytical standard can be used as follows:

• Simultaneous analysis of amoxicillin and clavulanate potassium in pharmaceutical formulations by capillary electrophoresis (CE) combined with capacitively coupled contactless conductivity detection (C⁴D)
• Development of a stability-indicating high-performance liquid chromatographic (HPLC) method combined with mass spectrometry (MS) to measure amoxicillin, clavulanate potassium, and their impurities in their combined dosage forms
• Residue analysis of potassium clavulanate and amoxicillin trihydrate by a UV spectrophotometric method in their bulk, combined tablet formulations, and human urine samples
• HPLC method-based determination of meropenem and potassium clavulanate in the presence of their degradation impurities in intravenous solutions in combination with a diode array detector (DAD)
• Determination of amoxicillin and clavulanic acid by capillary zone electrophoresis (CZE) in their combined commercial formulations

Biochem/physiol Actions

β-lactamase inhibitor, typically added to amoxicillin to increase its effectiveness.

Other Notes

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS02,GHS08
• Signal Word: Danger
• Hazard Statements: H228,H252,H317,H334
• Precautionary Statements: P210 - P235 - P240 - P241 - P280 - P302 + P352
• Hazard Classifications: Flam. Sol. 2 - Resp. Sens. 1 - Self-heat. 2 - Skin Sens. 1
• Supplementary Hazards: EUH044
• Storage Class Code: 4.2 - Pyrophoric and self-heating hazardous materials
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves