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Safety Information

C0434

Sigma-Aldrich

Chorionic gonadotropin human

lyophilized powder, from human pregnancy urine

Synonym(s):

Choriogonin, HCG

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About This Item

CAS Number:
9002-61-3
EC Number:
232-660-2
MDL number:
MFCD00130797
UNSPSC Code:
12352209
NACRES:
NA.32
biological source:
human pregnancy urine
form:
lyophilized powder

biological source

human pregnancy urine

Quality Level

200

sterility

sterile-filtered

form

lyophilized powder

potency

~13,000 I.U. per mg

mol wt

37.9 kDa

impurities

HBsAg, HCV and HIV-1/HIV-2, tested negative

solubility

water: 2 mg/mL, clear, colorless

UniProt accession no.

P01215

shipped in

ambient

storage temp.

−20°C

Gene Information

human ... CGA(1081)

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General description

Glycoprotein hormone consisting of a 92-amino acid α-chain which is identical to that of LH, FSH, and TSH; and a distinct 149-amino acid β-chain. Produced by chorionic tissue and responsible for maintaining the corpus luteum during early pregnancy. Also produced by trophoblast cell neoplasms, which are marked by elevated free hCG β-chains and hyperglycosylated hCG.

Biochem/physiol Actions

Human chorionic gondadotropin (hCG) may be used as an alternative to PMSG to induce ovulation in laboratory animals. When hCG was injected into laboratory animals via intravenous (i.v.), intraperitoneal (i.p.), or subcutaneous (s.c.) methodstet, the effective dose values for 50% of the animals (ED50) per animal and per body weight (kg) in parenthesis were as follows:
Mice: i.v. 0.2 (7.7) I.U.; i.p. 0.3 (11.5) I.U.; s.c. 0.7 (26.9) I.U.
Syrian hamsters: i.v. 1.0 (9.5) I.U.; i.p. 1.8 (17.1) I.U.; s.c. 2.6 (24.8) I.U.
Rats: i.v. 1.3 (4.6) I.U.; i.p. 3.5 (12.3) I.U.; s.c.7.5 (26.3) I.U.

Using PMSG, the ED50 values per animal and per body weight (kg) in parenthesis were as follows:
Mice: i.v. 0.8 (30.8) I.U.; i.p. 2.0 (76.9) I.U.; s.c. 2.8 (107.7) I.U
Syrian hamsters: i.v., 3.6 (34.3) I.U.; i. p., 8.0 (76.2) I.U.; s.c., 13.2 (125.7) I.U.
Rats: i.v., 6.0 (76.8) I.U.; i p., 20.8 (73.0) I.U.; s.c., 76.8 (269.5) I.U.

Linkage

Similar to C2047, but from a different supplier.

Pictograms

Health hazard
GHS08

Signal Word

Warning

Hazard Statements

H361

Precautionary Statements

P281

Hazard Classifications

Repr. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

C0434-50UG:
C0434-50UG-PW:
C0434-BULK:
C0434-.1MG:
C0434-.5MG:
C0434-.5MG-PW:
C0434-VAR:
C0434-.1MG-PW:

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Certificates of Analysis (COA)

Lot/Batch Number
SLCK9293
SLCK0225
SLCK0106
SLCH6805
SLCH4833

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Though the human fetus is exposed to placentally derived human chorionic gonadotropin (hCG) throughout gestation, the role of hCG on the fetal brain is unknown. Review of the available literature appears to indicate that groups of women with higher mean
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Molecular human reproduction, 23(10), 685-697 (2017-10-19)
Are four urinary hCG/menotropin (hMG) and one recombinant preparation characterized by different molecular features and do they mediate specific intracellular signaling and steroidogenesis? hCG and hMG preparations have heterogeneous compositions and mediate preparation-specific cell signaling and early steroidogenesis, although similar
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Luteinizing hormone receptor (LHR) plays a critical role in reproduction by mediating LH signaling in the gonad. In this study, we cloned a novel lhr gene from the orange-spotted grouper, named glhr2. The cloned complete open reading frame sequence of
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