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B6769

Sigma-Aldrich

des-Arg9-[Leu8]-Bradykinin acetate salt

≥97% (HPLC)

Synonym(s):

Arg-Pro-Pro-Gly-Phe-Ser-Pro-Leu

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About This Item

Empirical Formula (Hill Notation):
C41H63N11O10
CAS Number:
115035-45-5
Molecular Weight:
870.01
MDL number:
MFCD00133250
UNSPSC Code:
12352209
PubChem Substance ID:
329773283
NACRES:
NA.26

product name

des-Arg9-[Leu8]-Bradykinin acetate salt, ≥97% (HPLC)

Quality Level

200

Assay

≥97% (HPLC)

form

powder

color

white

storage temp.

−20°C

SMILES string

CC(O)=O.CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H]4CCCN4C(=O)[C@@H](N)CCCNC(N)=N)C(O)=O

InChI

1S/C41H63N11O10.C2H4O2/c1-24(2)20-28(40(61)62)48-36(57)31-14-8-17-50(31)38(59)29(23-53)49-34(55)27(21-25-10-4-3-5-11-25)47-33(54)22-46-35(56)30-13-7-18-51(30)39(60)32-15-9-19-52(32)37(58)26(42)12-6-16-45-41(43)44;1-2(3)4/h3-5,10-11,24,26-32,53H,6-9,12-23,42H2,1-2H3,(H,46,56)(H,47,54)(H,48,57)(H,49,55)(H,61,62)(H4,43,44,45);1H3,(H,3,4)/t26-,27-,28-,29-,30-,31-,32-;/m0./s1

InChI key

XBFMNOKHQZCARQ-XXZMQFNDSA-N

Related Categories

Amino Acid Sequence

Arg-Pro-Pro-Gly-Phe-Ser-Pro-Leu

Application

The Bradkykinin amid peptide des-Arg9-[Leu8]-Bradykinin is used as a bradykinin-1 receptor (B1R) antagonist frequently in comparison with the B1 receptor agonist des-Arg9-bradykinin.

Biochem/physiol Actions

Bradykinin receptor antagonist.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

B6769-25MG:
B6769-1MG:
B6769PROC:
B6769-PH:
B6769-VAR:
B6769-.5MG:
B6769-25MG-PW:
B6769-5MG:
B6769-BULK:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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M M Campos et al.
British journal of pharmacology, 117(5), 793-798 (1996-03-01)
1. The effect of pretreatment with bacterial endotoxin (LPS, 10 micrograms, i.v., 24 h) on the bradykinin B1 and B2 receptor-induced oedema in the rat paw, and the interaction of B1-mediated responses with other inflammatory mediators, was investigated. 2. Intraplantar
Juliano Ferreira et al.
Neuropharmacology, 54(3), 597-604 (2008-01-01)
The peripheral injection of phorbol myristate acetate (PMA) into the mouse paw induces nociception mediated through activation of protein kinase C (PKC). In the present study, we examine the contribution of kinin B1 receptor to PMA-induced nociception. Nociception was assessed
Thomas A Barker et al.
Hypertension (Dallas, Tex. : 1979), 48(5), 942-949 (2006-09-20)
It has been suggested that the effects of angiotensin II type 1 receptor (AT1R) blockers are in part because of angiotensin II type 2 receptor (AT2R) signaling. Interactions between the AT2R and kinins modulate cardiovascular function. Because AT2R expression increases

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