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B3412

Sigma-Aldrich

Berberine hemisulfate salt

≥95%

Synonym(s):

Natural Yellow 18

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About This Item

Linear Formula:
C20H18NO4 · 1/2SO4
CAS Number:
633-66-9
Molecular Weight:
384.39
Colour Index Number:
75160
MDL number:
MFCD00031743
UNSPSC Code:
12171500
PubChem Substance ID:
24891718
NACRES:
NA.32

Quality Level

100

Assay

≥95%

form

powder

solubility

methanol: soluble

SMILES string

[O-]S([O-])(=O)=O.COc1ccc2cc3-c4cc5OCOc5cc4CC[n+]3cc2c1OC.COc6ccc7cc8-c9cc%10OCOc%10cc9CC[n+]8cc7c6OC

InChI

1S/2C20H18NO4.H2O4S/c2*1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2;1-5(2,3)4/h2*3-4,7-10H,5-6,11H2,1-2H3;(H2,1,2,3,4)/q2*+1;/p-2

InChI key

OJVABJMSSDUECT-UHFFFAOYSA-L

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Application

Fluorescent stain for heparin in mast cells

Biochem/physiol Actions

An alkaloid with weak antibiotic properties. Substrate for MDR efflux pumps. Antimicrobial activities of berberine is potentiated by the MDR inhibitor 5´-methoxyhydnocarpin (5´-MHC). Berberine upregulates the expression of Pgp in hepatoma cells. Treatment with berberine potentially results in the reduced accumulation of chemotherapeutic drugs.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

B3412-BULK:
B3412-25G:
B3412-VAR:
B3412-5G:
B3412-10G:

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Certificates of Analysis (COA)

Lot/Batch Number
MKCK2558
MKCG7480
MKCF1144
SLBD0359V
071M1296V

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