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Key Documents

Safety Information

61760

Sigma-Aldrich

Lectin from Canavalia ensiformis

lyophilized, ≥50% (GE), powder

Synonym(s):

Agglutinin from jack beans, Con A

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About This Item

MDL number:
MFCD00071069
UNSPSC Code:
12352202
NACRES:
NA.56

biological source

Canavalia ensiformis

Quality Level

100

form

powder

quality

lyophilized

mol wt

Mr ~53000

concentration

≥50% (GE)

technique(s)

XRF: suitable

storage temp.

2-8°C

Biochem/physiol Actions

Con A is not blood group specific but has an affinity for terminal α-D-mannosyl and α-D-glucosyl residues. Ca2+ and Mn2+ ions are required for activity. Con A dissociates into dimers at pH 5.6 or below. Between pH 5.8 and pH 7.0, Con A exists as a tetramer; above pH 7.0 higher aggregates are formed. Con A exhibits mitogenic activity which is dependent on its degree of aggregation. Succinylation results in an active dimeric form which remains a dimer above pH 5.6.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

61760-BULK:
61760-VAR:
61760-100MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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H. Bittiger and H.P. Schnebli, eds.
Concanavalin A as a Tool, 639-639 (1976)
Lectins in the isolation of receptors on lymphocytes.
J J Marchalonis
Methods in enzymology, 150, 463-477 (1987-01-01)
Dongxu Wang et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 144, 111576-111576 (2020-08-05)
Plant-derived dietary lectins have been reported to be involved in the pathogenesis of several inflammatory diseases, including hepatitis, inflammatory bowel disease, diabetes, and celiac disease. In this present study, we aimed to assess whether green tea polyphenols (GTPs) exerts protective

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