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L8275

Sigma-Aldrich

Lectin from Galanthus nivalis (snowdrop)

lyophilized powder

Synonym(s):

Galanthus nivalis lectin, GNL

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About This Item

MDL number:
MFCD00163718
UNSPSC Code:
12352202
NACRES:
NA.32

form

lyophilized powder

Quality Level

200

potency

<20 μg per mL agglutination activity

composition

Protein, ≥90% Lowry

impurities

salt, essentially free

storage temp.

2-8°C

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General description

Lectin from Galanthus nivalis (snowdrop) is a tetrameric, 12 kDa mannose binding lectin. It belongs to the family, Amaryllidacea. It is specific to α-1,3- or 1,6- linked D-mannose of carbohydrates. Snowdrop lectins are toxic to insects.

Application

Lectin from Galanthus nivalis (snowdrop) has been used:
  • to coat ELISA plates
  • as reverse transcriptase inhibitor
  • in ELISA for detection of envelope glycoproteins of the human and simian immunodeficiency viruses

Biochem/physiol Actions

Lectin from Galanthus nivalis (snowdrop) provide resistance against pests and are used in transgenic plants. Snowdrop lectin functions as a carrier to transport fused proteins to the hemolymph as it crosses gut epithelium of target species to exhibit insecticidal effects.
GNL agglutinates rabbit erythrocytes; human erythrocytes are not agglutinated. GNL sugar specificity is directed to the nonreducing end of the terminal α-D-mannosyl residue of glycoconjugates.

Preparation Note

Purified by affinity chromatography according to Kaku.

Analysis Note

Agglutination activity is expressed in μg/ml and is determined from serial dilution in phosphate buffered saline, pH 7.2 of a 1 mg per mL solution. This activity is the lowest concentration to agglutinate a 2% suspension of rabbit erythrocytes after 1 hr incubation at 25 °C.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

L8275-5MG:
L8275-VAR:
L8275-BULK:
L8275-5MG-PW:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A model for the hepatitis C virus envelope glycoprotein E2
Yagnik AT, et al.
Proteins: Structure, Function, and Bioinformatics, 40, 355-366 (2000)
Expression of snowdrop lectin (GNA) in transgenic rice plants confers resistance to rice brown planthopper
Rao KV, et al.
The Plant Journal, 15, 469-477 (1998)
Synergistic antiviral effect of Galanthus nivalis agglutinin and nelfinavir against feline coronavirus
Antiviral Research, 88, 25-30 (2010)
Comparison of serological tests for the diagnosis of feline immunodeficiency virus infection of cats
Sibille P, et al.
Veterinary Microbiology, 45(2-3), 25-267 (1995)
Direct effects of snowdrop lectin (GNA) on larvae of three aphid predators and fate of GNA after ingestion
Hogervorst PAM, et al.
Journal of Insect Physiology, 52, 614-624 (2006)
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