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Key Documents

Safety Information

22244

Sigma-Aldrich

Ceramide from bovine spinal cord

≥98.0% (TLC)

Synonym(s):

Bovine Spinal Cord Ceramide

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About This Item

MDL number:
MFCD00146359
UNSPSC Code:
12352211
NACRES:
NA.25

biological source

bovine spinal cord

Quality Level

100

Assay

≥98.0% (TLC)

form

solid

impurities

α-hydroxy fatty acids

solubility

chloroform/methanol (99:1): 20 mg/mL, clear, colorless

lipid type

sphingolipids

shipped in

wet ice

storage temp.

−20°C

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Application

Ceramide is used to investigate effects on programmed cell death (apoptosis) and insulin signaling.

Biochem/physiol Actions

Ceramide is a minor component of cell membranes. Activates atypical protein kinase C (e.g., PKCzeta) .

Preparation Note

from cerebrosides by a modification of the procedure by H.E. Carter et al., J. Lipid Res. 2, 228 (1961)

Other Notes

Sales restrictions may apply

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

22244-5G:
22244-BULK:
22244-25MG:
22244-VAR:
22244-100MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Darren J Powell et al.
Molecular and cellular biology, 23(21), 7794-7808 (2003-10-16)
Ceramide is generated in response to numerous stress-inducing stimuli and has been implicated in the regulation of diverse cellular responses, including cell death, differentiation, and insulin sensitivity. Recent evidence indicates that ceramide may regulate these responses by inhibiting the stimulus-mediated
M G Yefimova et al.
Human reproduction (Oxford, England), 35(6), 1346-1362 (2020-06-13)
Do human granulosa cells (GCs) ingest and destroy apoptotic oocytes? Somatic GCs ingest and destroy apoptotic oocytes and other apoptotic substrates through unconventional autophagy-assisted phagocytosis. Most (99%) ovarian germ cells undergo apoptosis through follicular atresia. The mode of cleaning of
Marta Pera et al.
The EMBO journal, 36(22), 3356-3371 (2017-10-12)
In the amyloidogenic pathway associated with Alzheimer disease (AD), the amyloid precursor protein (APP) is cleaved by β-secretase to generate a 99-aa C-terminal fragment (C99) that is then cleaved by γ-secretase to generate the β-amyloid (Aβ) found in senile plaques.

Articles

Mitochondrial Stress and ROS

Oxidative stress is mediated, in part, by reactive oxygen species produced by multiple cellular processes and controlled by cellular antioxidant mechanisms such as enzymatic scavengers or antioxidant modulators. Free radicals, such as reactive oxygen species, cause cellular damage via cellular.

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