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345547

Sigma-Aldrich

Hydrogen chloride solution

4.0 M in dioxane

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About This Item

Empirical Formula (Hill Notation):
HCl
CAS Number:
7647-01-0
Molecular Weight:
36.46
MDL number:
MFCD00011324
UNSPSC Code:
12352301
PubChem Substance ID:
329755029
NACRES:
NA.21

form

liquid

Quality Level

200

concentration

3.80-4.40 M (by NaOH, titration)
4.0 M in dioxane

density

1.05 g/mL at 25 °C

SMILES string

Cl

InChI

1S/ClH/h1H

InChI key

VEXZGXHMUGYJMC-UHFFFAOYSA-N

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General description

Hydrogen chloride solution contains 4.0 M hydrogen chloride in 1,4-dioxane as the solvent. It is commonly used as a deprotection reagent during the deprotection of the tert-butoxycarbonyl (Boc) group of various amino acids and peptides. Additionally, it serves as a reagent in various organic synthesis reactions, including the synthesis of N-9-Fluorenylmethoxycarbonyl- (Fmoc) amino-acid chlorides.

Application

Hydrogen chloride solution (4.0 M in dioxane) can be used as:     
  • A reagent for the deprotection of the N-Boc protecting group from various heterocyclic derivatives.     
  • A reagent for the deprotection of polymer protecting groups. For instance, deprotection of benzyl ether-protected polymer.      
  • A polymerization initiator in combination with ZnCl2 in the synthesis of formyl terminated poly(ethyl vinyl ether) from ethyl vinyl ether (EVE).

Signal Word

Danger

Hazard Classifications

Carc. 1B - Eye Irrit. 2 - Flam. Liq. 2 - Met. Corr. 1 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Supplementary Hazards

EUH019

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

62.6 °F - closed cup

Flash Point(C)

17 °C - closed cup

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PDSCL

Deleterious substance

PRTR

Class I Designated Chemical Substances

FSL

Group 4: Flammable liquids
Type 1 petroleums
Hazardous rank II
Water insoluble liquid

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

345547-2L:4548173138282
345547-4X100ML:
345547-VAR-D:
345547-CH:
345547-800ML:4548173138299
345547-BULK:
345547-20L:
345547-100ML:4548173138275
345547-VAR:

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Certificates of Analysis (COA)

Lot/Batch Number
STBK6628
STBK6627
STBK1770
STBK1769
STBK0013

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