Merck
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PHR1028

Supelco

1,4-Benzoquinone

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):
Quinone, p-Benzoquinone
Linear Formula:
C6H4(=O)2
CAS Number:
Molecular Weight:
108.09
Beilstein:
773967
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

Quality Level

grade

certified reference material
pharmaceutical secondary standard

Agency

traceable to USP 1056504

vapor density

3.73 (vs air)

vapor pressure

0.1 mmHg ( 25 °C)

CofA

current certificate can be downloaded

autoignition temp.

815 °F

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

113-115 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

O=C1C=CC(=O)C=C1

InChI

1S/C6H4O2/c7-5-1-2-6(8)4-3-5/h1-4H

InChI key

AZQWKYJCGOJGHM-UHFFFAOYSA-N

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General description

1,4-Benzoquinone is a cyclic conjugated diketone. It belongs to the class of quinones, naturally occurring in plants, fungi, and bacteria.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB7811 in the slot below. This is an example certificate only and may not be the lot that you receive.

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Flam. Sol. 1 - Muta. 2 - Skin Corr. 1B - Skin Sens. 1 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

4.1B - Flammable solid hazardous materials

WGK

WGK 3

Flash Point(F)

170.6 °F - closed cup

Flash Point(C)

77 °C - closed cup

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

More Documents

Quotes and Ordering

Quinone chemistry and toxicity
Monks JT, et al.
Toxicology and Applied Pharmacology, 112(1), 2-16 (1992)
Vandana Bhalla et al.
Dalton transactions (Cambridge, England : 2003), 42(13), 4464-4469 (2013-02-16)
The binding behavior of nanoaggregates of pentacenequinone derivative 1 having thiophene groups has been investigated toward various cations (Fe(3+), Fe(2+), Pd(2+), Mg(2+), Cd(2+), Hg(2+), Ni(2+), Zn(2+), Cu(2+), Pb(2+), Co(2+), K(+), Na(+) and Li(+)) using UV-vis and fluorescence spectroscopy. Among the
S Saif Hasan et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(11), 4297-4302 (2013-02-27)
As much as two-thirds of the proton gradient used for transmembrane free energy storage in oxygenic photosynthesis is generated by the cytochrome b6f complex. The proton uptake pathway from the electrochemically negative (n) aqueous phase to the n-side quinone binding
K Roberg et al.
Free radical biology & medicine, 27(11-12), 1228-1237 (2000-01-21)
Apoptosis was induced in human foreskin fibroblasts by the redox-cycling quinone naphthazarin (5,8-dihydroxy-1,4-naphthoquinone). Most of the cells displayed ultrastructure typical of apoptosis after 8 h of exposure to naphthazarin. Apoptosis was inhibited in fibroblasts pretreated with the cathepsin D inhibitor
K He et al.
Biochemical pharmacology, 62(2), 191-198 (2001-06-08)
Oxidative ring opening of troglitazone (TGZ)(1) a thiazolidine 2,4-dione derivative used for the treatment of type II diabetes mellitus, leads to the formation of a quinone metabolite. The formation of TGZ quinone was shown to be NADPH dependent and to

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