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MATFLAGELLIN

Millipore

NEP Control Flagellin- PyroMAT® System MAT

Non-endotoxin pyrogen control of flagellin for use in monocyte activation test

Synonym(s):

NEP, NEP Control

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About This Item

UNSPSC Code:
41116130
eCl@ss:
32160606
NACRES:
NA.24

Assay

≥95% (SDS-PAGE)

Quality Level

400

usage

sufficient for 10 tests

feature

Non-endotoxin pyrogen control of flagellin for use in monocyte activation test

manufacturer/tradename

PyroMAT®

application(s)

pharmaceutical
pyrogen testing

compatibility

configured for PyroDetect System
configured for PyroMAT® System

shipped in

cooler

storage temp.

−20°C

suitability

pyrogenic bacteria

General description

The PyroMAT® System uses cryopreserved Mono-Mac-6 (MM6) human monocytic cells as a source of monocytes. The response to a full range of pyrogens, including endotoxins and non-endotoxin pyrogens (NEPs)is determined by the measurement of interleukin-6 (IL-6) produced by the Mono-Mac-6 cells using ELISA.
NEP control flagellin is a preparation of flagellin from Salmonella typhimurium and supplied in a lyophilized form. Flagellin is a non-endotoxin pyrogen (NEP) that activates the TLR5 receptor of monocytes and can be used as a positive control with the PyroMAT® System (Monocyte Activation Test for pyrogen detection).

Specificity

TLR-5 agonist

Application

NEP control of flagellin can be used as a positive control with the PyroMAT® System. It is to be used for Product Specific Validation (PSV) and routine testing to show that the system can detect non-endotoxin pyrogen contaminants in pharmaceutical products.

Features and Benefits

Endotoxin-free product at concentration of use in MAT Purity: ≥ 95% (SDS-PAGE)

Storage and Stability

Store unopened vials at -20°C
Do not use unopened vials after expiration date
Store resuspended aliquots at -20°C
Shelf life of aliquots can be found on the technical datasheet

Legal Information

PYROMAT is a registered trademark of Merck KGaA, Darmstadt, Germany

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Reference Standard Endotoxin, EDQM endotoxin standard for Monocyte Activation Test

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PyroDetect Cryoblood, Cryopreserved blood pooled from 8 donors for Monocyte Activation Test (MAT), for Pyrogen testing, package of 2 vials

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PYR0MATIL6

PyroMAT® Interleukin IL-6 standard, Interleukin-6 standard for use in the Monocyte Activation Test (MAT) for Pyrogen testing

MATHKSA

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MATRESIQUIM0D

Resiquimod Non-Endotoxin Pyrogen (NEP) Control, for use with PyroMAT®

MATFSL1

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related product

Product No.
Description
Pricing

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

MATFLAGELLIN:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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