Skip to Content
Merck
All Photos(1)

Key Documents

More Documents

Safety Information

EI6

Sigma-Aldrich

Chymostatin

lyophilized powder, protease inhibitor, Chemicon®

Synonym(s):

Protease Inhibitor

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

UNSPSC Code:
51111800
eCl@ss:
32160405
NACRES:
NA.77

product name

Chymostatin,

manufacturer/tradename

Chemicon®

Quality Level

100

shipped in

dry ice

General description

Chymostatin. M.W. 604.92

Mixture of types A, B and C. Inhibits Chymotrypsin-like serine proteases including alpha, beta, gamma and delta chymotrtrypsins.

Sequence:

[(S)-1-Carboxy-2-Phenylethyl]-Carbamoyl-a-[2-Iminohexahydro-4(S)-Pyrimidyl]-(S)-Glycyl-X-Phenylalaninal

X: L-Leu (type A), L-Ile (type B), L-Val (type C)

Working concentrations 10-100μM.

Stable for several hours. Soluble in DMSO and glacial acetic acid. Solutions are stable for a month at -20ºC.

5mg/825 microliters in DMSO = 10mM solution.

Dilute 1:100 for 100μM working solution.

Biochem/physiol Actions

Inhibitor Type: Protease Inhibitors

Physical form

Lyophilized. Dissolve in dimethylsulfoxide (DMSO). After powder is thoroughly dissolved, dilute the DMSO solution with 0.9% NaCl. The concentration of DMSO should be maintained at 10% or higher. Otherwise chymostatin may precipitate from the solution.



Example: Reconstitute 1 mg of chymostatin with 1.65 mL of DMSO. Then add 14.85 mL of 0.9% NaCl. This furnishes a 10-4 M solution. No preservatives added.

Storage and Stability

Maintain lyophilized material at -20ºC for up to one year. Store reconstituted product in aliquots at -20ºC for up to 3-4 weeks. Do not thaw and refreeze.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

EI6:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Chymostatin, a new chymotrypsin inhibitor produced by actinomycetes.
H Umezawa et al.
The Journal of antibiotics, 23(8), 425-427 (1970-08-01)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service