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Safety Information

573108-M

Millipore

STAT5 Inhibitor

The STAT5 Inhibitor, also referenced under CAS 285986-31-4, controls the biological activity of STAT5.

Synonym(s):

STAT5 Inhibitor, Nʹ-((4-Oxo-4H-chromen-3-yl)methylene)nicotinohydrazide

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About This Item

Empirical Formula (Hill Notation):
C16H11N3O3
CAS Number:
285986-31-4
Molecular Weight:
293.28
UNSPSC Code:
12352200

Quality Level

100

Assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 25 mg/mL

storage temp.

2-8°C

General description

A cell-permeable nonpeptidic nicotinoyl hydrazone compound that selectively targets the SH2 domain of STAT5 (IC50 = 47 µM against STAT5b SH2 domain EPO peptide binding activity), while exhibiting much less effect towards the SH2 domain of STAT1, STAT3, or Lck (IC50 >500 µM). Shown to block STAT5/STAT5 DNA binding activity in K562 nuclear extract and inhibit IFN-α-stimulated STAT5, but not STAT1 or STAT3, tyrosine phosphorylation in Daudi cells.

Warning

Toxicity: Standard Handling (A)

Other Notes

Muller, J., et al. 2008. ChemBioChem9, 723.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

573108-VMG:
573108-10MG-M:
573108-1.1ML:
573108-10MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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