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539142

Sigma-Aldrich

Proteasome Substrate III, Fluorogenic

≥98% (HPLC), amorphous solid, proteasome substrate, Calbiochem®

Synonym(s):

Proteasome Substrate III, Fluorogenic, Suc-LLVY-AMC, Chymotrypsin Substrate III, Fluorogenic

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About This Item

Empirical Formula (Hill Notation):
C40H53N5O10
Molecular Weight:
763.88
UNSPSC Code:
12352200
NACRES:
NA.77

product name

Proteasome Substrate III, Fluorogenic, Proteasome Substrate III, Fluorogenic, is a substrate for proteasome. Also acts as a substrate for calpain, chymotrypsin, and ingensin.

Quality Level

100

Assay

≥98% (HPLC)

form

amorphous solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 50 mg/mL

fluorescence

λex ~380 nm
λem ~460 nm

shipped in

ambient

storage temp.

−20°C

General description

Fluorogenic proteasome substrate. Also acts as a substrate for calpain, chymotrypsin, and ingensin.

Specificity

Inhibits serine proteases and cysteine proteases.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Proteasome
Product does not compete with ATP.
Reversible: no

Warning

Toxicity: Standard Handling (A)

Sequence

Suc-Leu-Leu-Val-Tyr-AMC

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Anderson, M., et al. 1999. Exp. Eye Res.69, 129.
Rock, K.L., et al. 1994. Cell 78, 761.
Tsubuki, S., et al. 1993. Biochem. Biophys. Res. Commun.196, 1195.
Sasaki, T., et al. 1984. J. Biol. Chem. 259, 12489.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

539142-MG:
539142-5MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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